Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function

Adipose tissue is a crucial organ in energy metabolism and thermoregulation. phenotype controlled by various signaling mechanisms under pathophysiological conditions. Type II transmembrane serine proteases (TTSPs) are group of trypsin-like enzymes anchoring on the cell surface. These act diverse tissues to regulate physiological processes, such as food digestion, salt-water balance, iron metabolism, epithelial integrity, auditory nerve development. More recently, several members TTSP family, namely, hepsin, matriptase-2, corin, have been shown play role regulating lipid adipose phenotype, thermogenesis, via direct growth factor activation or indirect hormonal mechanisms. In mice, hepsin deficiency increases browning protects from high-fat diet-induced hyperglycemia, hyperlipidemia, obesity. Similarly, matriptase-2 fat lipolysis reduces obesity hepatic steatosis diet-fed mice. contrast, corin white weights sizes, suppresses adipocyte thermogenic responses, causes cold intolerance findings highlight an important TTSPs modifying cellular function tissue. this review, we provide brief description about discuss recent regarding responses.